AICDA

Across TCGA patient cohorts, AICDA mutation is significantly associated with the RNA expression of many other genes, with 2,926 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AICDA-associated genes across cancer lineages are MIR98, UHRF1, and USP9YP10. Each is linked with AICDA in more than 1 cancer types. Because this analysis shows association rather than direction, both AICDA-to-partner and partner-to-AICDA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR98 grouped by AICDA-low versus AICDA-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AICDA→partner) and Y-score (partner→AICDA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR98 →	+0.419	+3.069	.001	.008	3	2
UCEC	UHRF1 →	+0.795	+1.858	<.001	.005	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
GBM	RN7SL229P →	+0.234	+5.584	<.001	.003	3	2
COAD	LINC02032 →	+0.132	+5.409	<.001	.001	3	2
COAD	RN7SL83P →	+0.366	+4.392	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,926 associations by consensus.

MIR98 by AICDA expression — LUSC

Explore this box plot interactively →