AHRR

Across TCGA patient cohorts, AHRR mutation is significantly associated with the RNA expression of many other genes, with 3,187 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHRR-associated genes across cancer lineages are STIL, C1orf174, and GAPDHP17. Each is linked with AHRR in more than 3 cancer types. Because this analysis shows association rather than direction, both AHRR-to-partner and partner-to-AHRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STIL grouped by AHRR-low versus AHRR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHRR→partner) and Y-score (partner→AHRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STIL →	+0.379	+1.758	.005	.003	3	4
UCEC	C1orf174 →	+0.304	+1.844	.001	<.001	3	4
SKCM	GAPDHP17 →	+0.019	+4.186	<.001	.007	3	3
COAD	SNRPCP20 →	+0.290	+2.831	<.001	<.001	3	3
UCEC	UBR7 →	+0.486	+2.141	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.463	+1.710	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,187 associations by consensus.

STIL by AHRR expression — UCEC

Explore this box plot interactively →