AHRR

Across TCGA pan-cancer cohorts, AHRR RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AHRR data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AHRR RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AHRR expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

HNSC, UVM, and KIRP are the cancer types where AHRR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.509	0.260	<.001	134	view →
UVM	DFS	Tertile	All	0.255	0.790	<.001	119	view →
KIRP	DFS	Quartile	II,III,IV	0.455	0.887	<.001	101	view →
KICH	DFS	Median	III,IV	0.340	0.853	.006	65	view →
BRCA	DFS	Median	All	0.465	0.593	<.001	38	view →
LGG	DFS	Tertile	All	0.358	0.594	<.001	34	view →
CHOL	OS	Tertile	All	0.548	1.000	.001	33	view →
MESO	DFS	Quartile	All	0.280	0.551	.004	32	view →
STAD	DFS	Median	III,IV	0.722	0.472	.005	30	view →
OV	OS	Median	All	0.253	0.389	<.001	28	view →
CESC	DFS	Quartile	All	0.607	0.832	.001	20	view →
SARC	DFS	Quartile	All	0.240	0.549	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AHRR–HNSC (DFS)

Open the HNSC breakdown →