AHRR

Across TCGA patient cohorts, AHRR mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHRR-associated genes across cancer lineages are CD49b, Caspase-7-cleavedD198, and c-Jun_pS73. Each is linked with AHRR in more than 2 cancer types. Because this analysis shows association rather than direction, both AHRR-to-partner and partner-to-AHRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by AHRR-low versus AHRR-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHRR→partner) and Y-score (partner→AHRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD49b →	+0.289	+3.330	.039	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.591	+3.087	<.001	<.001	3	3
LUSC	c-Jun_pS73 →	-0.211	-2.972	.024	.036	3	2
UCEC	FoxM1 →	+0.155	+1.184	.045	.022	3	2
UCEC	MEK1 →	+0.320	+1.652	.003	.005	3	2
UCEC	PCNA →	+0.196	+1.999	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

CD49b by AHRR expression — COAD

Explore this box plot interactively →