AHRR

Across TCGA cell cohorts, AHRR mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AHRR-associated genes across cancer lineages are C9orf92, TOPAZ1, and OR8S1. Each is linked with AHRR in more than 1 cancer types. Because this analysis shows association rather than direction, both AHRR-to-partner and partner-to-AHRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by AHRR-low versus AHRR-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHRR→partner) and Y-score (partner→AHRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	C9orf92 →	+0.108	+5.000	.003	.006	3	1
SKIN	TOPAZ1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	OR8S1 →	+0.014	+4.437	<.001	.004	3	1
BLOOD_Leukemia	C9 →	+1.413	+3.775	<.001	.004	3	1
BLOOD_Leukemia	CPN1 →	+0.104	+3.820	.001	.004	3	1
BLOOD_Leukemia	BHLHE23 →	+1.072	+3.691	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

C9orf92 by AHRR expression — PANCREAS

Explore this box plot interactively →