AHR

Across TCGA patient cohorts, AHR mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHR-associated genes across cancer lineages are Mre11, ATM, and FOXO3a. Each is linked with AHR in more than 2 cancer types. Because this analysis shows association rather than direction, both AHR-to-partner and partner-to-AHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mre11 grouped by AHR-low versus AHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHR→partner) and Y-score (partner→AHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Mre11 →	-0.067	-1.321	.009	.012	3	3
UCEC	ATM →	-0.435	-1.893	.001	.014	3	3
SKCM	FOXO3a →	-0.125	-2.321	.029	.035	3	3
BLCA	PDCD4 →	+0.366	+1.749	.039	.049	3	2
BLCA	PRAS40_pT246 →	+0.135	+1.999	.016	.031	3	2
UCEC	14-3-3_beta →	-0.101	-1.821	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Mre11 by AHR expression — UCEC

Explore this box plot interactively →