AHR

Across TCGA pan-cancer cohorts, AHR RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of AHR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AHR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AHR is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where AHR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AHR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.595	<.001	11	view →
KIRC	Male	IV	+1.467	<.001	9	view →
STAD	Male	II,III,IV	+1.320	<.001	8	view →
THCA	Male	All	+1.039	<.001	8	view →
KIRP	Male	All	+1.315	<.001	7	view →
KICH	All	All	−1.063	<.001	7	view →
ESCA	All	All	+1.648	.001	5	view →
READ	Male	All	+1.023	<.001	5	view →
LUSC	All	All	−0.499	<.001	5	view →
COAD	Male	All	+0.667	.001	4	view →
BRCA	Female	All	−0.468	<.001	4	view →
PAAD	All	All	+1.365	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

AHR–HNSC

Open the HNSC breakdown →