AHR

Across TCGA cell cohorts, AHR RNA expression is significantly associated with the go_rna of many other GO terms, with 5,494 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AHR-associated GO terms across cancer lineages are Cellular response to 2,3,7,8-tetrachlorodibenzodioxine, Glial cell development, and Response to 2,3,7,8-tetrachlorodibenzodioxine. Each is linked with AHR in more than 17 cancer types. Because this analysis shows association rather than direction, both AHR-to-partner and partner-to-AHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to 2,3,7,8-tetrachlorodibenzodioxine grouped by AHR-low versus AHR-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AHR→partner) and Y-score (partner→AHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Cellular response to 2,3,7,8-tetrachlorodibenzodioxine →	+1.333	+2.204	<.001	<.001	3	18
KIDNEY	Glial cell development →	+0.105	+1.221	<.001	<.001	3	13
BLOOD_Myeloma	Response to 2,3,7,8-tetrachlorodibenzodioxine →	+1.136	+1.782	<.001	<.001	3	13
BREAST	Positive regulation of CD4-positive, alpha-beta T cell activation →	+0.126	+1.419	<.001	.001	3	12
SOFT_TISSUE	Intracellular receptor signaling pathway →	+0.057	+2.420	<.001	<.001	3	12
SOFT_TISSUE	Viral gene expression →	+0.060	+1.650	.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,494 associations by consensus.

Cellular response to 2,3,7,8-tetrachlorodibenzodioxine by AHR expression — CNS

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