AHR

Across TCGA cell cohorts, AHR mutation is significantly associated with the RNA expression of many other genes, with 217 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHR-associated genes across cancer lineages are HELT, CFC1B, and COX4I2. Each is linked with AHR in more than 1 cancer types. Because this analysis shows association rather than direction, both AHR-to-partner and partner-to-AHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by AHR-low versus AHR-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHR→partner) and Y-score (partner→AHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HELT →	+0.090	+3.491	<.001	.008	3	2
BLOOD_Lymphoma	CFC1B →	+0.020	+4.662	<.001	.003	3	2
URINARY_TRACT	COX4I2 →	+0.090	+5.087	<.001	.004	3	1
PANCREAS	ART1 →	+0.025	+4.426	.001	.001	3	1
PANCREAS	TAAR8 →	+0.014	+4.029	<.001	.007	3	1
PANCREAS	ZNF683 →	+0.093	+3.700	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 217 associations by consensus.

HELT by AHR expression — PANCREAS

Explore this box plot interactively →