AHNAK

Across TCGA patient cohorts, AHNAK mutation is significantly associated with the total protein of many other genes, with 119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHNAK-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with AHNAK in more than 5 cancer types. Because this analysis shows association rather than direction, both AHNAK-to-partner and partner-to-AHNAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by AHNAK-low versus AHNAK-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHNAK→partner) and Y-score (partner→AHNAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GAPDH →	+0.284	+1.201	.030	.026	3	6
COAD	Caspase-7-cleavedD198 →	+1.192	+2.123	<.001	<.001	3	6
UCEC	Cyclin-B1 →	+0.521	+1.056	<.001	<.001	3	6
STAD	4E-BP1 →	+0.352	+2.087	<.001	.005	3	6
CESC	Caveolin-1 →	-0.803	-3.169	.008	.016	3	5
BLCA	TFRC →	+0.417	+1.860	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

GAPDH by AHNAK expression — BLCA

Explore this box plot interactively →