AHNAK

Across TCGA pan-cancer cohorts, AHNAK RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated AHNAK data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher AHNAK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AHNAK expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

BLCA, KIRC, and UCS are the cancer types where AHNAK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.328	0.521	<.001	140	view →
KIRC	OS	Median	All	0.721	0.539	<.001	62	view →
UCS	DFS	Median	IV	0.952	0.367	.001	50	view →
PAAD	OS	Median	All	0.338	0.637	<.001	49	view →
ESCA	OS	Median	III,IV	0.715	0.397	<.001	41	view →
OV	OS	Median	III,IV	0.261	0.364	.001	38	view →
BRCA	DFS	Tertile	III,IV	0.670	0.427	<.001	35	view →
MESO	OS	Quartile	III,IV	0.455	0.743	.020	17	view →
DLBC	DFS	Quartile	All	0.344	1.000	.011	11	view →
ACC	DFS	Quartile	All	0.216	0.647	.019	10	view →
THYM	DFS	Tertile	III,IV	1.000	0.362	.004	10	view →
SARC	OS	Quartile	All	0.826	0.593	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

AHNAK–BLCA (OS)

Open the BLCA breakdown →