AHNAK

Across TCGA cell cohorts, AHNAK mutation is significantly associated with the mutation status of many other genes, with 4,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHNAK-associated genes across cancer lineages are CHD8, MUC4, and ITPR3. Each is linked with AHNAK in more than 5 cancer types. Because this analysis shows association rather than direction, both AHNAK-to-partner and partner-to-AHNAK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHD8 grouped by AHNAK-low versus AHNAK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHNAK→partner) and Y-score (partner→AHNAK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHD8 →	+3.154	+1.919	<.001	<.001	1	6
BLOOD_Leukemia	MUC4 →	+0.931	+1.212	.009	.009	1	6
BLOOD_Lymphoma	ITPR3 →	+2.714	+2.200	.004	.004	1	6
SKIN	SBF1 →	+2.896	+1.963	.001	.001	1	5
URINARY_TRACT	LAMA1 →	+3.807	+2.415	.002	.002	1	5
BLOOD_Leukemia	TRPS1 →	+2.443	+1.777	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,112 associations by consensus.

CHD8 by AHNAK expression — BLOOD_Leukemia

Explore this box plot interactively →