AHCYL1

Across TCGA patient cohorts, AHCYL1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHCYL1-associated genes across cancer lineages are A-Raf_pS299, 14-3-3_beta, and eEF2. Each is linked with AHCYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AHCYL1-to-partner and partner-to-AHCYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by AHCYL1-low versus AHCYL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCYL1→partner) and Y-score (partner→AHCYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.132	-3.321	.002	.009	3	2
UCEC	14-3-3_beta →	-0.115	-3.673	.001	.001	3	1
UCEC	eEF2 →	+0.447	+3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.261	+2.700	<.001	.005	3	1
UCEC	GAPDH →	+0.506	+3.321	.010	.009	3	1
UCEC	ACC1 →	+0.308	+3.013	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

A-Raf_pS299 by AHCYL1 expression — UCEC

Explore this box plot interactively →