AHCYL1

Across TCGA pan-cancer cohorts, AHCYL1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AHCYL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AHCYL1 RNA is repressed in tumor relative to normal tissue. In most cancer types AHCYL1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where AHCYL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AHCYL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.313	<.001	10	view →
KIRC	Male	III,IV	−0.775	<.001	9	view →
LIHC	Female	II,III,IV	+0.697	<.001	8	view →
CHOL	All	All	+1.132	<.001	5	view →
KIRP	Male	All	−0.479	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

AHCYL1–KICH

Open the KICH breakdown →