AHCTF1

Across TCGA patient cohorts, AHCTF1 mutation is significantly associated with the RNA expression of many other genes, with 5,453 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AHCTF1-associated genes across cancer lineages are CEP76, LIN7C, and SLC7A11. Each is linked with AHCTF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AHCTF1-to-partner and partner-to-AHCTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP76 grouped by AHCTF1-low versus AHCTF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHCTF1→partner) and Y-score (partner→AHCTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP76 →	+0.461	+3.230	.003	.009	3	4
STAD	LIN7C →	+0.640	+3.484	<.001	.002	3	4
STAD	SLC7A11 →	+1.028	+2.601	.004	.006	3	4
STAD	GFM2 →	+0.526	+2.618	.002	.005	3	4
UCEC	ZNF654 →	+0.415	+1.364	<.001	<.001	3	4
UCEC	TYMSOS →	+0.534	+1.499	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,453 associations by consensus.

CEP76 by AHCTF1 expression — COAD

Explore this box plot interactively →