AGTR2

Across TCGA patient cohorts, AGTR2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGTR2-associated genes across cancer lineages are Caspase-8, c-Met, and PI3K-p85. Each is linked with AGTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGTR2-to-partner and partner-to-AGTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by AGTR2-low versus AGTR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR2→partner) and Y-score (partner→AGTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.244	-3.432	.001	<.001	3	2
UCEC	c-Met →	-0.181	-1.905	.048	.004	3	2
SKCM	PI3K-p85 →	+0.182	+1.820	.016	.014	3	1
SKCM	AMPK_alpha →	+0.100	+1.584	.047	.018	3	1
SKCM	AMPK_pT172 →	+0.283	+1.584	.016	.018	3	1
SKCM	B-Raf →	+0.280	+2.459	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-8 by AGTR2 expression — UCEC

Explore this box plot interactively →