AGTR2

Across TCGA cell cohorts, AGTR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,132 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AGTR2-associated GO terms across cancer lineages are Regulation of RNA splicing, RNA 3'-end processing, and Positive regulation of DNA-templated transcription, elongation. Each is linked with AGTR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AGTR2-to-partner and partner-to-AGTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by AGTR2-low versus AGTR2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR2→partner) and Y-score (partner→AGTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of RNA splicing →	+0.073	+0.807	<.001	.002	3	4
SOFT_TISSUE	RNA 3'-end processing →	+0.084	+1.602	<.001	<.001	3	3
SOFT_TISSUE	Positive regulation of DNA-templated transcription, elongation →	+0.050	+0.800	<.001	.002	3	3
SOFT_TISSUE	Dihydrofolate metabolic process →	+0.118	+1.257	.002	.002	3	3
SOFT_TISSUE	Glycosylceramide catabolic process →	+0.159	+1.588	<.001	<.001	3	3
SOFT_TISSUE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.078	+1.411	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,132 associations by consensus.

Regulation of RNA splicing by AGTR2 expression — SOFT_TISSUE

Explore this box plot interactively →