AGTR2

Across TCGA cell cohorts, AGTR2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AGTR2-associated genes across cancer lineages are ZNRF4, CLEC1B, and KRTAP13-2. Each is linked with AGTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGTR2-to-partner and partner-to-AGTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by AGTR2-low versus AGTR2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR2→partner) and Y-score (partner→AGTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNRF4 →	+0.022	+4.781	<.001	.003	3	1
BREAST	CLEC1B →	+0.013	+4.199	<.001	.007	3	1
BREAST	KRTAP13-2 →	+0.154	+4.672	<.001	.002	3	1
BREAST	CD300H →	+0.378	+4.199	<.001	.007	3	1
SKIN	FCN2 →	+0.060	+6.022	<.001	.001	3	1
LARGE_INTESTINE	NAA11 →	+0.474	+3.706	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ZNRF4 by AGTR2 expression — BREAST

Explore this box plot interactively →