AGTR1

Across TCGA patient cohorts, AGTR1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGTR1-associated genes across cancer lineages are Gab2, p38-MAPK, and ASNS. Each is linked with AGTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGTR1-to-partner and partner-to-AGTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by AGTR1-low versus AGTR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR1→partner) and Y-score (partner→AGTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.285	+1.415	.033	.046	3	2
UCEC	p38-MAPK →	-0.149	-2.564	.015	.010	3	2
UCEC	ASNS →	+0.334	+2.000	.013	.030	3	2
UCEC	Cyclin-B1 →	+0.782	+2.662	<.001	<.001	3	2
LUSC	Mre11 →	+0.149	+2.834	.018	.034	3	1
SKCM	Raptor →	-0.224	-2.459	.009	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Gab2 by AGTR1 expression — UCEC

Explore this box plot interactively →