AGTR1

Across TCGA cell cohorts, AGTR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,161 significant associations in total. CNS shows the largest number of these associations.

The most reproducible AGTR1-associated GO terms across cancer lineages are Phospholipase C-activating angiotensin-activated signaling pathway, Maintenance of blood vessel diameter homeostasis by renin-angiotensin, and Response to transforming growth factor beta. Each is linked with AGTR1 in more than 6 cancer types. Because this analysis shows association rather than direction, both AGTR1-to-partner and partner-to-AGTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phospholipase C-activating angiotensin-activated signaling pathway grouped by AGTR1-low versus AGTR1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR1→partner) and Y-score (partner→AGTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Phospholipase C-activating angiotensin-activated signaling pathway →	+1.564	+3.381	<.001	<.001	3	7
BREAST	Maintenance of blood vessel diameter homeostasis by renin-angiotensin →	+0.764	+1.688	.002	.002	3	5
SOFT_TISSUE	Response to transforming growth factor beta →	+0.070	+1.128	<.001	.001	3	5
SOFT_TISSUE	Collagen fibril organization →	+0.150	+0.880	<.001	.004	3	4
SOFT_TISSUE	Renal system process involved in regulation of systemic arterial blood pressure →	+0.708	+0.958	.003	.001	3	4
SOFT_TISSUE	Protein exit from endoplasmic reticulum →	+0.094	+1.043	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,161 associations by consensus.

Phospholipase C-activating angiotensin-activated signaling pathway by AGTR1 expression — LIVER

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