AGTPBP1

Across TCGA cell cohorts, AGTPBP1 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGTPBP1-associated genes across cancer lineages are MAGEB5, PIRT, and DKK4. Each is linked with AGTPBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGTPBP1-to-partner and partner-to-AGTPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by AGTPBP1-low versus AGTPBP1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTPBP1→partner) and Y-score (partner→AGTPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
LUNG_SCLC	DKK4 →	+0.150	+3.781	<.001	.003	3	1
LUNG_SCLC	HSFY1 →	+0.091	+3.232	.002	.008	3	1
LUNG_SCLC	OR10H5 →	+0.037	+3.459	.009	.003	3	1
LUNG_SCLC	KRTAP21-2 →	+0.084	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MAGEB5 by AGTPBP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →