AGR3

Across TCGA patient cohorts, AGR3 mutation is significantly associated with the RNA expression of many other genes, with 110 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGR3-associated genes across cancer lineages are RN7SKP119, MIR5688, and OR7E149P. Each is linked with AGR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGR3-to-partner and partner-to-AGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP119 grouped by AGR3-low versus AGR3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGR3→partner) and Y-score (partner→AGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP119 →	+0.295	+3.971	<.001	.005	3	2
SKCM	MIR5688 →	+0.439	+4.436	<.001	.001	3	2
UCEC	OR7E149P →	+0.118	+3.344	<.001	.008	3	1
SKCM	ASS1P3 →	+0.048	+3.287	.002	.008	3	1
SKCM	UGT1A1 →	+0.045	+3.490	<.001	.008	3	1
SKCM	RN7SL105P →	+0.155	+4.449	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 110 associations by consensus.

RN7SKP119 by AGR3 expression — BLCA

Explore this box plot interactively →