AGPS

Across TCGA patient cohorts, AGPS mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGPS-associated genes across cancer lineages are mTOR_pS2448, ATM, and eEF2. Each is linked with AGPS in more than 1 cancer types. Because this analysis shows association rather than direction, both AGPS-to-partner and partner-to-AGPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by AGPS-low versus AGPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGPS→partner) and Y-score (partner→AGPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.149	-3.446	.010	.005	3	2
UCEC	ATM →	-0.640	-3.169	<.001	<.001	3	2
UCEC	eEF2 →	+0.340	+3.321	.015	.009	3	1
UCEC	EGFR_pY1068 →	-0.195	-2.000	.047	.010	3	1
UCEC	eIF4E →	+0.219	+2.502	.008	.002	3	1
UCEC	ERK2 →	+0.208	+2.000	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by AGPS expression — UCEC

Explore this box plot interactively →