AGPS

Across TCGA pan-cancer cohorts, AGPS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AGPS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AGPS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AGPS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, STAD, and KIRP are the cancer types where AGPS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AGPS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.028	<.001	12	view →
STAD	Male	II,III,IV	+1.035	<.001	9	view →
KIRP	Male	II,III,IV	+0.929	<.001	9	view →
KIRC	All	All	+0.492	<.001	9	view →
THCA	All	II,III,IV	−0.473	<.001	8	view →
KICH	Female	II,III,IV	−1.577	<.001	7	view →
LIHC	Male	All	+0.752	<.001	7	view →
BLCA	Female	All	+0.739	.003	6	view →
CHOL	All	All	+1.395	<.001	5	view →
ESCA	All	All	+1.207	.005	4	view →
LUAD	Male	All	+0.466	.001	4	view →
PRAD	All	All	−0.583	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

AGPS–HNSC

Open the HNSC breakdown →