AGPAT4

Across TCGA patient cohorts, AGPAT4 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGPAT4-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and Smad3. Each is linked with AGPAT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGPAT4-to-partner and partner-to-AGPAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AGPAT4-low versus AGPAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGPAT4→partner) and Y-score (partner→AGPAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.691	+3.827	.001	<.001	3	3
UCEC	PCNA →	+0.216	+2.000	.005	.029	3	2
UCEC	Smad3 →	+0.110	+1.807	.043	.025	3	2
UCEC	ATM →	-0.522	-1.807	.001	.025	3	2
UCEC	Caspase-8 →	-0.289	-3.060	.001	<.001	3	2
UCEC	Chk2_pT68 →	-0.163	-3.295	.014	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Caspase-7-cleavedD198 by AGPAT4 expression — UCEC

Explore this box plot interactively →