AGPAT4

Across TCGA pan-cancer cohorts, AGPAT4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AGPAT4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AGPAT4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AGPAT4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where AGPAT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AGPAT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.172	<.001	12	view →
THCA	Male	II,III,IV	−1.752	<.001	11	view →
LUAD	All	III,IV	−0.997	<.001	9	view →
KIRC	Male	II,III,IV	−0.771	<.001	9	view →
KICH	Female	III,IV	−2.480	<.001	8	view →
LIHC	Female	All	+0.777	<.001	8	view →
BRCA	All	II,III,IV	−0.573	<.001	6	view →
LUSC	Male	All	−0.675	<.001	4	view →
CHOL	Male	All	+2.171	<.001	3	view →
UCEC	All	All	−0.833	<.001	2	view →
PRAD	All	All	−0.372	<.001	2	view →
READ	Female	All	−1.327	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AGPAT4–HNSC

Open the HNSC breakdown →