AGPAT4-IT1

Across TCGA pan-cancer cohorts, AGPAT4-IT1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AGPAT4-IT1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher AGPAT4-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AGPAT4-IT1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and CHOL show a favorable association.

CESC, KIRC, and LUAD are the cancer types where AGPAT4-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.460	0.701	<.001	76	view →
KIRC	DFS	Tertile	All	0.561	0.726	.003	58	view →
LUAD	OS	Quartile	All	0.782	0.885	.006	48	view →
THCA	DFS	Tertile	II,III,IV	0.800	0.996	<.001	41	view →
UVM	OS	Quartile	III,IV	0.387	0.768	.006	41	view →
MESO	OS	Median	All	0.324	0.647	.014	28	view →
ACC	DFS	Tertile	IV	0.126	0.632	.002	24	view →
HNSC	OS	Quartile	III,IV	0.352	0.640	.006	23	view →
ESCA	OS	Median	III,IV	0.674	0.453	.012	18	view →
LAML	DFS	Tertile	All	0.328	0.709	.001	18	view →
BLCA	DFS	Quartile	All	0.243	0.385	.020	14	view →
READ	DFS	Median	IV	0.391	0.827	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AGPAT4-IT1–CESC (OS)

Open the CESC breakdown →