AGPAT2

Across TCGA patient cohorts, AGPAT2 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. COAD shows the largest number of these associations.

The most reproducible AGPAT2-associated genes across cancer lineages are RPL31P45, MRPL51P2, and MIR4480. Each is linked with AGPAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGPAT2-to-partner and partner-to-AGPAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL31P45 grouped by AGPAT2-low versus AGPAT2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGPAT2→partner) and Y-score (partner→AGPAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL31P45 →	+0.402	+4.271	<.001	.003	3	2
BLCA	MRPL51P2 →	+0.114	+7.640	<.001	.009	3	2
SKCM	MIR4480 →	+0.520	+6.469	<.001	.001	3	1
BLCA	RNU6-478P →	+0.333	+7.640	<.001	.009	3	1
UCEC	MIR4306 →	+0.359	+3.666	.007	.004	3	1
UCEC	MIR5591 →	+0.379	+5.148	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

RPL31P45 by AGPAT2 expression — COAD

Explore this box plot interactively →