AGO3

Across TCGA patient cohorts, AGO3 protein abundance is significantly associated with the RNA expression of many other genes, with 15,067 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible AGO3-associated genes across cancer lineages are PDGFRB, PLSCR4, and CNRIP1. Each is linked with AGO3 in more than 7 cancer types. Because this analysis shows association rather than direction, both AGO3-to-partner and partner-to-AGO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGO3 versus PDGFRB in CCRCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO3→partner) and Y-score (partner→AGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PDGFRB →	+1.111	+0.189	<.001	<.001	3	8
UCEC	PLSCR4 →	+0.973	+0.266	<.001	<.001	3	8
UCEC	CNRIP1 →	+0.832	+0.315	<.001	<.001	3	8
CCRCC	DDR2 →	+0.938	+0.156	<.001	.001	3	8
CCRCC	JAM3 →	+0.975	+0.188	<.001	<.001	3	8
BRCA	ANTXR1 →	+1.246	+0.229	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,067 associations by consensus.

AGO3 vs PDGFRB — CCRCC

Explore this scatter interactively →