AGO3

Across TCGA patient cohorts, AGO3 mutation is significantly associated with the RNA expression of many other genes, with 1,289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGO3-associated genes across cancer lineages are ITGAE, ETFA, and STAU2P1. Each is linked with AGO3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGO3-to-partner and partner-to-AGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGAE grouped by AGO3-low versus AGO3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO3→partner) and Y-score (partner→AGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAE →	+0.515	+2.938	<.001	<.001	3	3
UCEC	ETFA →	+0.545	+2.087	<.001	.005	3	2
CESC	STAU2P1 →	+0.093	+4.779	<.001	.001	3	2
UCEC	CCL5 →	+1.344	+2.480	<.001	<.001	3	2
UCEC	LINC01607 →	-0.781	-3.066	<.001	<.001	3	2
UCEC	LINC00869 →	-0.492	-2.006	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,289 associations by consensus.

ITGAE by AGO3 expression — UCEC

Explore this box plot interactively →