AGO3

Across TCGA patient cohorts, AGO3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGO3-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with AGO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both AGO3-to-partner and partner-to-AGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AGO3-low versus AGO3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO3→partner) and Y-score (partner→AGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.098	+2.815	.011	.036	1	4
UCEC	EGFR_pY1068 →	-0.225	-2.000	.014	.030	3	2
UCEC	JNK_pT183_Y185 →	-0.153	-2.000	.013	.030	3	2
UCEC	MSH6 →	-0.343	-2.000	.004	.029	3	2
UCEC	mTOR →	-0.165	-2.321	.005	.033	3	2
UCEC	PCNA →	+0.251	+2.415	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by AGO3 expression — COAD

Explore this box plot interactively →