AGO3

Across TCGA cell cohorts, AGO3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,457 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGO3-associated GO terms across cancer lineages are RISC complex assembly, Pre-miRNA processing, and Response to dehydroepiandrosterone. Each is linked with AGO3 in more than 19 cancer types. Because this analysis shows association rather than direction, both AGO3-to-partner and partner-to-AGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RISC complex assembly grouped by AGO3-low versus AGO3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO3→partner) and Y-score (partner→AGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RISC complex assembly →	+0.159	+1.532	<.001	<.001	3	20
BONE	Pre-miRNA processing →	+0.142	+1.109	<.001	<.001	3	18
BONE	Response to dehydroepiandrosterone →	+0.213	+1.064	<.001	<.001	3	17
BREAST	Centrosome cycle →	+0.090	+0.929	<.001	<.001	3	17
URINARY_TRACT	Regulation of metaphase plate congression →	+0.149	+1.086	.001	.008	3	17
URINARY_TRACT	mRNA alternative polyadenylation →	+0.081	+1.082	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,457 associations by consensus.

RISC complex assembly by AGO3 expression — URINARY_TRACT

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