AGO3

Across TCGA cell cohorts, AGO3 mutation is significantly associated with the mutation status of many other genes, with 3,917 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGO3-associated genes across cancer lineages are PPARD, ATG9A, and PHF20L1. Each is linked with AGO3 in more than 3 cancer types. Because this analysis shows association rather than direction, both AGO3-to-partner and partner-to-AGO3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPARD grouped by AGO3-low versus AGO3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO3→partner) and Y-score (partner→AGO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPARD →	+3.906	+3.316	.004	.004	1	4
BLOOD_Leukemia	ATG9A →	+6.285	+5.560	<.001	<.001	1	4
SKIN	PHF20L1 →	+4.906	+3.655	.001	.001	1	4
BLOOD_Leukemia	FN1 →	+2.285	+3.364	.006	.006	1	4
LUNG_NSCLC_LUAD	DNAI1 →	+4.772	+5.339	.004	.004	1	3
LARGE_INTESTINE	VPS13D →	+1.712	+3.676	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,917 associations by consensus.

PPARD by AGO3 expression — SKIN

Explore this box plot interactively →