AGO2

Across TCGA patient cohorts, AGO2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,603 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AGO2-associated genes across cancer lineages are PTK2, EEF1D, and CHRAC1. Each is linked with AGO2 in more than 7 cancer types. Because this analysis shows association rather than direction, both AGO2-to-partner and partner-to-AGO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGO2 versus PTK2 in HNSC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO2→partner) and Y-score (partner→AGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTK2 →	+0.591	+0.202	<.001	<.001	3	8
OV	EEF1D →	+0.715	+0.347	.001	<.001	3	7
LSCC	CHRAC1 →	+0.597	+0.218	<.001	<.001	3	6
LUAD	ENY2 →	+0.492	+0.228	<.001	<.001	3	6
OV	DERL1 →	+0.676	+0.368	<.001	<.001	3	6
LSCC	EIF3H →	+0.626	+0.333	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,603 associations by consensus.

AGO2 vs PTK2 — HNSC

Explore this scatter interactively →