AGO2

Across TCGA pan-cancer cohorts, AGO2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AGO2 data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AGO2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AGO2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

KIRP, ACC, and CESC are the cancer types where AGO2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.765	0.934	<.001	116	view →
ACC	DFS	Median	All	0.232	0.665	<.001	100	view →
CESC	DFS	Tertile	All	0.728	0.871	<.001	92	view →
LIHC	OS	Quartile	All	0.562	0.824	<.001	79	view →
MESO	OS	Median	All	0.273	0.490	<.001	74	view →
UVM	DFS	Quartile	III,IV	0.216	0.771	.001	53	view →
KICH	DFS	Quartile	II,III,IV	0.404	0.915	.002	50	view →
LGG	OS	Tertile	All	0.348	0.524	<.001	33	view →
BRCA	OS	Quartile	II,III,IV	0.491	0.728	<.001	32	view →
SARC	OS	Tertile	All	0.423	0.854	<.001	29	view →
UCEC	DFS	Tertile	All	0.612	0.778	<.001	28	view →
SCLC	OS	Quartile	All	0.758	0.462	.008	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AGO2–KIRP (DFS)

Open the KIRP breakdown →