AGO2

Across TCGA patient cohorts, AGO2 mutation is significantly associated with the RNA expression of many other genes, with 5,774 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGO2-associated genes across cancer lineages are RPL17-C18orf32, CENPU, and CHAF1B. Each is linked with AGO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGO2-to-partner and partner-to-AGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL17-C18orf32 grouped by AGO2-low versus AGO2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO2→partner) and Y-score (partner→AGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL17-C18orf32 →	+0.124	+2.228	<.001	.006	3	3
UCEC	CENPU →	+0.578	+1.617	<.001	<.001	3	3
UCEC	CHAF1B →	+0.545	+1.440	<.001	<.001	3	3
UCEC	LCORL →	+0.324	+1.906	<.001	.001	3	3
UCEC	FNIP2 →	+0.537	+3.000	<.001	<.001	3	3
COAD	CDC7 →	+0.913	+3.183	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,774 associations by consensus.

RPL17-C18orf32 by AGO2 expression — SKCM

Explore this box plot interactively →