AGO2

Across TCGA patient cohorts, AGO2 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGO2-associated genes across cancer lineages are ATM, Cyclin-E2, and INPP4B. Each is linked with AGO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AGO2-to-partner and partner-to-AGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by AGO2-low versus AGO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO2→partner) and Y-score (partner→AGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.489	-2.794	<.001	<.001	3	4
COAD	Cyclin-E2 →	+0.268	+2.832	.019	.034	3	3
COAD	INPP4B →	-0.513	-3.161	.005	.019	3	2
COAD	Rad50 →	-0.357	-3.161	.002	.019	3	2
COAD	CDK1 →	+0.195	+3.178	.029	.010	3	2
COAD	c-Kit →	-0.845	-3.000	.004	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

ATM by AGO2 expression — UCEC

Explore this box plot interactively →