AGO2

Across TCGA cell cohorts, AGO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,988 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AGO2-associated GO terms across cancer lineages are miRNA-mediated gene silencing by mRNA destabilization, miRNA processing, and P-body assembly. Each is linked with AGO2 in more than 17 cancer types. Because this analysis shows association rather than direction, both AGO2-to-partner and partner-to-AGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, miRNA-mediated gene silencing by mRNA destabilization grouped by AGO2-low versus AGO2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO2→partner) and Y-score (partner→AGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	miRNA-mediated gene silencing by mRNA destabilization →	+0.156	+1.351	<.001	<.001	3	18
URINARY_TRACT	miRNA processing →	+0.103	+0.874	<.001	.003	3	17
LUNG_SCLC	P-body assembly →	+0.131	+0.804	<.001	.001	3	16
OVARY	RISC complex assembly →	+0.137	+0.999	<.001	<.001	3	16
SOFT_TISSUE	Regulation of sister chromatid cohesion →	+0.098	+0.774	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of trophoblast cell migration →	+0.127	+0.960	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,988 associations by consensus.

miRNA-mediated gene silencing by mRNA destabilization by AGO2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →