AGO2

Across TCGA cell cohorts, AGO2 mutation is significantly associated with the RNA expression of many other genes, with 633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGO2-associated genes across cancer lineages are GAGE12H, OC90, and OR10G4. Each is linked with AGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGO2-to-partner and partner-to-AGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12H grouped by AGO2-low versus AGO2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO2→partner) and Y-score (partner→AGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAGE12H →	+1.137	+2.896	<.001	.008	3	2
CNS	OC90 →	+0.022	+4.169	<.001	.008	3	1
CNS	OR10G4 →	+0.010	+5.357	<.001	.001	3	1
CNS	FAM240A →	+0.020	+4.169	<.001	.008	3	1
LARGE_INTESTINE	TOP3B →	+0.712	+2.158	.001	.004	3	1
LARGE_INTESTINE	DEPDC5 →	+0.536	+2.158	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 633 associations by consensus.

GAGE12H by AGO2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →