AGO1

Across TCGA patient cohorts, AGO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,741 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AGO1-associated proteins across cancer lineages are WDR70, SF3B3, and KHDRBS1. Each is linked with AGO1 in more than 6 cancer types. Because this analysis shows association rather than direction, both AGO1-to-partner and partner-to-AGO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AGO1 versus WDR70 in LSCC, with a Pearson correlation of 0.48.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO1→partner) and Y-score (partner→AGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR70 →	+0.477	+0.708	<.001	<.001	3	7
LSCC	SF3B3 →	+0.182	+0.420	<.001	<.001	3	6
GBM	KHDRBS1 →	+0.225	+0.341	<.001	<.001	3	6
HNSC	ZMYM4 →	+0.345	+0.666	<.001	<.001	3	5
GBM	SF3B1 →	+0.148	+0.245	.002	.005	3	5
GBM	SNRNP200 →	+0.219	+0.372	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,741 associations by consensus.

AGO1 vs WDR70 — LSCC

Explore this scatter interactively →