AGO1

Across TCGA cell cohorts, AGO1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGO1-associated genes across cancer lineages are LRRC3B, MDGA2, and OR2C1. Each is linked with AGO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGO1-to-partner and partner-to-AGO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3B grouped by AGO1-low versus AGO1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGO1→partner) and Y-score (partner→AGO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRRC3B →	+0.033	+4.350	.001	.005	3	1
LARGE_INTESTINE	MDGA2 →	+0.182	+3.854	<.001	.006	3	1
LARGE_INTESTINE	OR2C1 →	+0.151	+3.725	<.001	.008	3	1
LARGE_INTESTINE	HTR1E →	+0.070	+3.345	<.001	.007	3	1
LARGE_INTESTINE	INSL5 →	+0.368	+3.626	<.001	.006	3	1
LARGE_INTESTINE	IQCF6 →	+0.228	+3.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

LRRC3B by AGO1 expression — BLOOD_Lymphoma

Explore this box plot interactively →