AGL

Across TCGA cell cohorts, AGL mutation is significantly associated with the RNA expression of many other genes, with 769 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGL-associated genes across cancer lineages are TIFAB, DEFB108B, and SPINK4. Each is linked with AGL in more than 1 cancer types. Because this analysis shows association rather than direction, both AGL-to-partner and partner-to-AGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIFAB grouped by AGL-low versus AGL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGL→partner) and Y-score (partner→AGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TIFAB →	+0.002	+2.830	<.001	.004	3	2
BLOOD_Lymphoma	DEFB108B →	+0.063	+3.169	<.001	.008	3	2
LUNG_NSCLC_LUAD	SPINK4 →	+1.802	+3.256	<.001	.009	3	2
LARGE_INTESTINE	BMPR1A →	+0.601	+2.244	.003	.003	3	2
LARGE_INTESTINE	FRG1 →	+0.362	+2.850	.005	<.001	3	2
LARGE_INTESTINE	ATG4C →	+0.531	+3.169	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 769 associations by consensus.

TIFAB by AGL expression — SKIN

Explore this box plot interactively →