AGK

Across TCGA pan-cancer cohorts, AGK mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AGK data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AGK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AGK expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and CCRCC are the cancer types where AGK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.922	.018	60	view →
LSCC	DFS	Tertile	II,III,IV	0.770	0.407	.028	8	view →
CCRCC	OS	Quartile	III,IV	0.047	1.000	.038	6	view →
LUAD	DFS	Median	All	0.669	0.951	.014	6	view →
PDAC	DFS	Median	II,III,IV	0.272	0.433	.033	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AGK–COAD (DFS)

Open the COAD breakdown →