AGK

Across TCGA pan-cancer cohorts, AGK RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AGK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AGK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AGK is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUAD, and BLCA are the cancer types where AGK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AGK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.835	<.001	12	view →
LUAD	Male	III,IV	+0.778	<.001	10	view →
BLCA	Female	All	+0.703	<.001	10	view →
COAD	Male	All	+0.565	<.001	9	view →
KIRP	All	All	+0.384	<.001	9	view →
LUSC	Female	All	+0.735	<.001	8	view →
LIHC	Female	II,III,IV	+0.841	<.001	7	view →
READ	All	All	+0.751	.003	6	view →
BRCA	All	II,III,IV	+0.270	<.001	6	view →
STAD	Female	All	+0.580	.013	4	view →
CHOL	Male	All	+1.698	<.001	2	view →
UCEC	All	III,IV	+0.404	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

AGK–HNSC

Open the HNSC breakdown →