AGK

Across TCGA cell cohorts, AGK mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible AGK-associated genes across cancer lineages are OR12D3, DEFA6, and PRAMEF11. Each is linked with AGK in more than 1 cancer types. Because this analysis shows association rather than direction, both AGK-to-partner and partner-to-AGK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by AGK-low versus AGK-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGK→partner) and Y-score (partner→AGK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR12D3 →	+0.016	+5.807	<.001	.001	3	1
OVARY	DEFA6 →	+0.111	+5.196	.004	.005	3	1
LUNG_SCLC	PRAMEF11 →	+0.026	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR12D3 by AGK expression — OVARY

Explore this box plot interactively →