AGFG1

Across TCGA cell cohorts, AGFG1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible AGFG1-associated genes across cancer lineages are ARGFX, PRAMEF4, and OR4F21. Each is linked with AGFG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGFG1-to-partner and partner-to-AGFG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARGFX grouped by AGFG1-low versus AGFG1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGFG1→partner) and Y-score (partner→AGFG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ARGFX →	+0.083	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF4 →	+0.186	+5.357	<.001	.003	3	2
LARGE_INTESTINE	OR4F21 →	+0.220	+3.878	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
CNS	F9 →	+0.029	+5.321	<.001	.005	3	1
CNS	IFNG →	+0.043	+5.321	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ARGFX by AGFG1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →