Across TCGA cell cohorts, AGER mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGER-associated genes across cancer lineages are TFDP3, OR2J3, and UBE2QL1. Each is linked with AGER in more than 1 cancer types. Because this analysis shows association rather than direction, both AGER-to-partner and partner-to-AGER results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGER→partner) and Y-score (partner→AGER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.023	+3.518	<.001	.001	3	1
LARGE_INTESTINE	OR2J3 →	+0.034	+4.505	<.001	<.001	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.246	+3.722	<.001	.007	3	1
LARGE_INTESTINE	OR5V1 →	+0.005	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

AGER survival (RNA) · tumor vs normal (RNA) · all AGER data types