AGAP5

Across TCGA patient cohorts, AGAP5 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP5-associated genes across cancer lineages are eEF2, INPP4B, and JNK2. Each is linked with AGAP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP5-to-partner and partner-to-AGAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AGAP5-low versus AGAP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP5→partner) and Y-score (partner→AGAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.377	+2.999	.023	.035	3	1
UCEC	INPP4B →	-0.310	-3.000	.039	.036	3	1
UCEC	JNK2 →	+0.263	+2.834	.004	.034	3	1
UCEC	Lck →	+0.227	+2.999	.015	.035	3	1
UCEC	MSH6 →	-0.441	-3.311	.004	.010	3	1
UCEC	NF2 →	+0.280	+2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eEF2 by AGAP5 expression — UCEC

Explore this box plot interactively →