Across TCGA patient cohorts, AGAP4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGAP4-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FoxM1. Each is linked with AGAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP4-to-partner and partner-to-AGAP4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP4→partner) and Y-score (partner→AGAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-2.321	.021	.035	3	1
UCEC	A-Raf_pS299 →	-0.144	-3.000	.016	.036	3	1
UCEC	FoxM1 →	+0.371	+2.321	.004	.035	3	1
UCEC	Notch1 →	+0.192	+2.321	.006	.035	3	1
UCEC	STAT3_pY705 →	-0.580	-3.459	<.001	.005	3	1
UCEC	Tuberin_pT1462 →	+0.261	+2.179	.024	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

AGAP4 survival (RNA) · tumor vs normal (RNA) · all AGAP4 data types