AGAP3

Across TCGA cell cohorts, AGAP3 mutation is significantly associated with the RNA expression of many other genes, with 1,003 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGAP3-associated genes across cancer lineages are CGRRF1, INVS, and EDEM1. Each is linked with AGAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP3-to-partner and partner-to-AGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CGRRF1 grouped by AGAP3-low versus AGAP3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP3→partner) and Y-score (partner→AGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CGRRF1 →	+0.585	+3.212	.004	.006	3	2
BLOOD_Leukemia	INVS →	+0.615	+3.548	.001	.001	3	2
LARGE_INTESTINE	EDEM1 →	+0.657	+3.212	.003	.006	3	2
LARGE_INTESTINE	BBS7 →	+0.708	+3.212	<.001	.006	3	2
LARGE_INTESTINE	INTS12 →	+0.465	+3.299	.003	.004	3	2
LARGE_INTESTINE	SLC39A6 →	+0.975	+3.064	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,003 associations by consensus.

CGRRF1 by AGAP3 expression — LARGE_INTESTINE

Explore this box plot interactively →